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Vidyadheesh Jagdish Kelkar

PhD student

Vidyadheesh Jagdish Kelkar, MSc.
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I obtained my Bachelor's and Master's (BS-MS) degree in Biology from the Indian Institute of Science Education and Research (IISER), Pune, India. For my Master's thesis, I investigated the behavioral aspects of the neurodegenerative disease Amyotrophic Lateral Sclerosis (ALS) using Drosophila melanogaster as a model system. My research focused on examining how neurodegeneration in ALS-affected flies influences motor functions, circadian rhythms, and sleep-wake cycles. Following my Master's, I continued as a research assistant at IISER, further advancing my work in this area.

My fascination with Drosophila as a model organism, along with my broader interests in genetics and evolution, motivated me to pursue a PhD in Evolutionary Genetics. This ultimately led me to join the Vienna Graduate School of Population Genetics.

During my PhD, I aim to investigate polygenic adaptation using two-genotype experimental evolution studies. My primary objective is to achieve a higher-resolution understanding of genome-wide allele frequency changes in evolving Drosophilapopulations. To achieve a more fine-grained resolution of the polygenic architecture I plan to minimize the genetic drift by working with exceptionally large population sizes (by Drosophila standards) along with a high number of replicate populations. We believe this approach will provide a more refined resolution of the polygenic architecture, offering deeper insights into recombination breakpoints and linkage dynamics.