Selected Publications

The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas.
Garces de Los Fayos Alonso I1,2,3, Liang HC4, Turner SD5, Lagger S6, Merkel O7, Kenner L8,9,10. Link Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/29597249

"ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling."
Schmidt, S; Schumacher, N; Schwarz, J; Tangermann, S; Kenner, L; Schlederer, M; Sibilia, M; Linder, M; Altendorf-Hofmann, A; Knösel, T; Gruber, ES; Oberhuber, G; Bolik, J; Rehman, A; Sinha, A [and 18 others] (2018):  J Exp Med. 2018; [Article in Press]

"Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia."
Gutjahr, JC; Szenes, E; Tschech, L; Asslaber, D; Schlederer, M; Roos, S; Yu, X; Girbl, T; Sternberg, C; Egle, A; Aberger, F; Alon, R; Kenner, L; Greil, R; Orian-Rousseau, V; Hartmann, TN (2018):  Blood. 2018;

"MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain."
Lagger, S; Connelly, JC; Schweikert, G; Webb, S; Selfridge, J; Ramsahoye, BH; Yu, M; He, C; Sanguinetti, G; Sowers, LC; Walkinshaw, MD; Bird, A (2017):  2017; 13(5):e1006793

"When the guardian sleeps: Reactivation of the p53 pathway in cancer."
Merkel, O; Taylor, N; Prutsch, N; Staber, PB; Moriggl, R; Turner, SD; Kenner, L (2017):  Mutat Res. 2017; 773:1-13

“Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress.”
Malcolm TI, Villarese P, Fairbairn CJ, Lamant L, Trinquand A, Hook CE, Burke GA, Brugières L, Hughes K, Payet D, Merkel O, Schiefer AI, Ashankyty I, Mian S, Wasik M, Turner M, Kenner L, Asnafi V, Macintyre E, Turner SD.
Nat Commun. 2016 Jan 12;7:10087. doi: 10.1038/ncomms10087.
Link Pubmed:http://www.ncbi.nlm.nih.gov/pubmed/?term=Malcolm+TI+2016

“Interleukin-6 receptor alpha blockade improves skin lesions in a murine model of systemic lupus erythematosus.”
Birner P, Heider S, Petzelbauer P, Wolf P, Kornauth C, Kuroll M, Merkel O, Steiner G, Kishimoto T, Rose-John S, Soleiman A, Moriggl R, Kenner L.
Exp Dermatol. 2016 Apr;25(4):305-10. doi: 10.1111/exd.12934. Epub 2016 Feb 13.
Link Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/26739431

“STAT3 regulated ARF expression suppresses prostate cancer metastasis.”
Pencik J, Schlederer M, Gruber W, Unger C, Walker SM, Chalaris A, Marié IJ, Hassler MR, Javaheri T, Aksoy O, Blayney JK, Prutsch N, Skucha A, Herac M, Krämer OH, Mazal P, Grebien F, Egger G, Poli V, Mikulits W, Eferl R, Esterbauer H, Kennedy R, Fend F, Scharpf M, Braun M, Perner S, Levy DE, Malcolm T, Turner SD, Haitel A, Susani M, Moazzami A, Rose-John S, Aberger F, Merkel O, Moriggl R, Culig Z, Dolznig H, Kenner L.
Nat Commun. 2015 Jul 22;6:7736. doi: 10.1038/ncomms8736.
Link Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/26198641

“Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy.”
Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D, Willimsky G, Ammirante M, Strasner A, Hansel DE, Jamieson C, Kane CJ, Klatte T, Birner P, Kenner L, Karin M.
Nature. 2015 May 7;521(7550):94-8. doi: 10.1038/nature14395. Epub 2015 Apr 29.
Link Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25924065

“Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.”
Crescenzo R, Abate F, Lasorsa E, Tabbo' F, Gaudiano M, Chiesa N, Di Giacomo F, Spaccarotella E, Barbarossa L, Ercole E, Todaro M, Boi M, Acquaviva A, Ficarra E, Novero D, Rinaldi A, Tousseyn T, Rosenwald A, Kenner L, Cerroni L, Tzankov A, Ponzoni M, Paulli M, Weisenburger D, Chan WC, Iqbal J, Piris MA, Zamo' A, Ciardullo C, Rossi D, Gaidano G, Pileri S, Tiacci E, Falini B, Shultz LD, Mevellec L, Vialard JE, Piva R, Bertoni F, Rabadan R, Inghirami G; European T-Cell Lymphoma Study Group, T-Cell Project: Prospective Collection of Data in Patients with Peripheral T-Cell Lymphoma and the AIRC 5xMille Consortium “Genetics-Driven Targeted Management of Lymphoid Malignancies”.
Cancer Cell. 2015 Apr 13;27(4):516-32. doi: 10.1016/j.ccell.2015.03.006.
Link Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25873174

“Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2;5) translocation.”
Merkel O, Hamacher F, Griessl R, Grabner L, Schiefer AI, Prutsch N, Baer C, Egger G, Schlederer M, Krenn PW, Hartmann TN, Simonitsch-Klupp I, Plass C, Staber PB, Moriggl R, Turner SD, Greil R, Kenner L.
J Pathol. 2015 Aug;236(4):445-56. doi: 10.1002/path.4539. Epub 2015 Apr 27.
Link Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25820993

“Reliable quantification of protein expression and cellular localization in histological sections.”
Schlederer M, Mueller KM, Haybaeck J, Heider S, Huttary N, Rosner M, Hengstschläger M, Moriggl R, Dolznig H, Kenner L.
PLoS One. 2014 Jul 11;9(7):e100822. doi: 10.1371/journal.pone.0100822.
Link Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/25013898

“Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man.”
Jais A, Einwallner E, Sharif O, Gossens K, Lu TT, Soyal SM, Medgyesi D, Neureiter D, Paier-Pourani J, Dalgaard K, Duvigneau JC, Lindroos-Christensen J, Zapf TC, Amann S, Saluzzo S, Jantscher F, Stiedl P, Todoric J, Martins R, Oberkofler H, Müller S, Hauser-Kronberger C, Kenner L, Casanova E, Sutterlüty-Fall H, Bilban M, Miller K, Kozlov AV, Krempler F, Knapp S, Lumeng CN, Patsch W, Wagner O, Pospisilik JA, Esterbauer H.
Cell. 2014 Jul 3;158(1):25-40. doi: 10.1016/j.cell.2014.04.043.
Link Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24995976

“A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis.”
Kollmann K, Heller G, Schneckenleithner C, Warsch W, Scheicher R, Ott RG, Schäfer M, Fajmann S, Schlederer M, Schiefer AI, Reichart U, Mayerhofer M, Hoeller C, Zöchbauer-Müller S, Kerjaschki D, Bock C, Kenner L, Hoefler G, Freissmuth M, Green AR, Moriggl R, Busslinger M, Malumbres M, Sexl V.
Cancer Cell. 2013 Aug 12;24(2):167-81. doi: 10.1016/j.ccr.2013.07.012.
Link Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23948297

“PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas.”
Laimer D, Dolznig H, Kollmann K, Vesely PW, Schlederer M, Merkel O, Schiefer AI, Hassler MR, Heider S, Amenitsch L, Thallinger C, Staber PB, Simonitsch-Klupp I, Artaker M, Lagger S, Turner SD, Pileri S, Piccaluga PP, Valent P, Messana K, Landra I, Weichhart T, Knapp S, Shehata M, Todaro M, Sexl V, Höfler G, Piva R, Medico E, Ruggeri BA, Cheng M, Eferl R, Egger G, Penninger JM, Jaeger U, Moriggl R, Inghirami G, Kenner L.
Nat Med. 2012 Nov;18(11):1699-704. doi: 10.1038/nm.2966. Epub 2012 Oct 14.
Link Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23064464